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Department of Chemistry

Department of Chemistry

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Prof HS Clayton

Associate Professor | College of Science, Engineering and Technology
School of Science | Department: Chemistry

Tel: 011 670 9310
Email: clayths@unisa.ac.za
Campus: Science, Florida
Building: Eureka
Office: K-M-036

  • PhD Chemistry (UCT)
  • MSc Chemistry (UCT)
  • BSc Hons Chemistry (UCT)
  • BSc Chemistry and Mathematics (UCT)

  • CHE1501 – General Chemistry 1A 
  • CHE4801 – Inorganic Chemistry Honours
  • CHE4808 – Inorganic Chemistry Honours Practical

  • Organometallic Chemistry
  • Structural Chemistry
  • Computational Chemistry

Current research centres on the organometallic chemistry of Platinum Group Metals. The focus is on the design, synthesis and structural characterisation of transition metal complexes with possible applications as catalysts, medicines and new materials. The work includes computational methods which are applied to investigate the chemical and physical properties of new transition metal complexes synthesized.

  1. Crystal structure of dibromido-carbonyl-(η6-pcymene)osmium(II); );  HS. Clayton; Zeitschrift für Kristallographie – New Crystal Structures (2018), 233, 221.
  2. Crystal structure of bromido(η6-1-isopropyl-4-methylbenzene)(7-oxocyclohepta- 1,3,5-trien-1-olato-κ2O,O')osmium; HS. Clayton, KC. Tapala and A. Lemmerer; Acta Cryst. (2018), E74, 275.
  3. Crystal structure of dibromido μ-oxalato-k2O,O': k2O'',O'''-h6-p-cymenediosmium(II);  HS. Clayton, KC. Tapala and A. Lemmerer; Zeitschrift für Kristallographie – New Crystal Structures (2016), 231, 1055.
  4. Theoretical and experimental studies on formation of diethylzinc-triphenylphosphine complex; V. Sadhana, D. Das, C. Sravania, A. Sivaramakrishna, K. Vijayakrishna and HS. Clayton; Phosphorus, Sulfur, and Silicon and the Related Elements (2016), 191, 35.
  5. Facile synthesis of platinum based heterobimetallic carbonyl clusters from bis(1-alkenyl)Pt(II) precursors; C. Sravani, S. Venkatesh, A. Sivaramakrishna, K. Vijayakrishna, HS. Clayton, JR. Moss, V. Momberg and H. Su; Polyhedron (2013), 62, 169.
  6. Investigations on synthesis, thermolysis, and coordination chemistry of aminophosphine oxides; EV. Goud, BB. Pavan Kumar, Y. Shruthi, A. Paul, A. Sivaramakrishna, K. Vijayakrishna, CVS. Brahmananda Rao, KN. Sabharwal and HS. Clayton; Journal of Coordination Chemistry (2013), 66, 2647.
  7. Review: active homogeneous reagents and catalysts in n-alkane activation; A. Sivaramakrishna, P. Suman, EV. Goud, S. Janardan, C. Sravani, T. Sandeep, K. Vijayakrishna and HS. Clayton; Journal of Coordination Chemistry (2013), 66, 2091.
  8. Synthesis, structure, chemistry, and applications of tetravalent nickel complexes; A. Sivaramakrishna, HS. Clayton and U. Muralikrishna; Journal of Coordination Chemistry (2011), 64, 1309.
  9. Hydrocarbon (p- and s-) complexes of nickel, palladium and platinum: Synthesis, reactivity and applications; A. Sivaramakrishna, HS. Clayton, MM. Mogorosi and JR. Moss; Coordination Chemistry Reviews (2010), 254, 2904.
  10. Synthesis, characterization, reactivity and molecular structure of arene-osmium complexes: A new synthetic entry into (η6-arene)osmium(II) chemistry; HS. Clayton, BCE. Makhubela, H. Su, GS. Smith and JR. Moss; Polyhedron (2009), 28, 1511.
  11. Platinum based mixed-metal clusters (PtnMm(CO)xLy, M=Ru or Os; n + m= 2 to 10 and Ly = other ligands) - Synthesis, structure, reactivity and applications; A. Sivaramakrishna, HS. Clayton, BCE. Makhubela and JR. Moss; Coordination Chemistry Reviews (2008) 252, 1460.
  12. Transition metal-alkenyl complexes [M–(CH2)nCH=CH2, n≥2]: Synthesis, structure, reactivity and applications; A. Sivaramakrishna, HS. Clayton, C. Kaschula and JR. Moss; Coordination Chemistry Reviews (2007), 251, 1294.
  13. Metallacycloalkanes – Synthesis, Structure and Reactivity of Medium to Large Ring Compounds; B. Blom, H. Clayton, M. Kilkenny and JR. Moss; Advances in Organometallic Chemistry (2006) 54, 149.
  14. Synthesis, characterization and reactivity of iron-olefin complexes of the type [CpFe(CO)2(η2-CH2=CHR)]+X- (Cp = η5-C5H5; R =CH3 to n-C14H29; X = PF6 or BF4); HS. Clayton, JR. Moss and ME. Dry; Journal of Organometallic Chemistry, (2003) 688, 181. 
  15. Molecular Structure, Spectroscopic, Frontier Molecular Orbital Analysis, Molecular Docking Studies, and In Vitro DNA-Binding Studies of Osmium(II)-Cymene Complexes with Aryl Phosphine and Aryl Phosphonium Assemblies.KC Tapala, NG Ndlangamandla, MP Ngoepe, HS Clayton; Bioinorg. Chem. Appl. (2024) 29, 6697523. 
  16. Crystal structure of dibromo-dicarbonyl-bis(tricyclohexylphosphine)-osmium(II) dichloromethane solvate. JM Monareng, HS Clayton; Zeitschrift für Kristallographie-New Crystal Structures (2023) 238, 689-692.

  17. Prophylactic and Therapeutic Potential Zinc Metallodrugs Drug Discovery: Identification of SARS-CoV-2 Replication and Spike/ACE2 Inhibitors. MP Ngoepe, KC Tapala, HS Clayton; Current Computer-Aided Drug Design (2022) 18, 519-534.

  18. Metal complexes as DNA synthesis and/or repair inhibitors: anticancer and antimicrobial agents. MP Ngoepe, HS Clayton Pharmaceutical Fronts (2021) 3, e164-e182.

  • The synthesis and structural characterization of new organometallic and coordination compounds with possible application as catalysts, medicines and as new materials.
  • The application of computational methods to investigate chemical behaviour.

Research

  • The synthesis and structural characterization of new organometallic and coordination compunds with possible application as catalysts, medicines and as new materials.
  • The application of computational methods to investigate chemical behaviour.